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The Purin Bodies of Food Stuffs

The Purin Bodies of Food Stuffs

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Excerpt from The Purin Bodies of Food Stuffs: Their Estimation, Action, and Significance

My object in undertaking the following investigation was to obtain further information as to the action of purin bodies and their metabolism, and to discover some means whereby the early pathological changes in certain metabolic disorders may be detected.

In endeavouring to solve these problems, I have made estimations of the purin bodies present in the more common foodstuffs, and studied their specific effects upon the metabolic processes in animals and man, when they are introduced into the body subcutaneously or taken by the mouth. Were it possible to recognise the first stages of the altered functions, the application of preventive and remedial measures would soon follow. The importance of the subject is emphasised by our knowledge of the secondary results of imperfectly katabolised substances upon the vascular and excretory systems. It has been aptly remarked that two-thirds of the cases of cardiac strain in the second half of life present a history of perverted metabolism.

I desire to specially express my indebtedness to Professor Stirling, Manchester, Geheimrath Hering and Professor Siegfried, Leipzig, Professors Johansson and Holmgren, Stockholm, for permission to work in their laboratories. My thanks are also due to them, as well as to Professor Santesson, Stockholm, and Dr. Burian, Leipzig, for their kindly interest and encouragement in an enquiry, which although by no means fulfilling the projected aims, will, I hope, furnish some basis for further work in a similar direction.

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